Distribution of 5,5 dimethyl-2,4-oxazolidinedione (DMO) in intraocular and cerebrospinal fluids of rabbits. 3. Effect of ammonium chloride and probenecid.

The effect of ammonium chloride (systemic acidosis) and probenecid on the distribution of DMO in intraocular and cerebrospinal fluids has been studied. These drugs increased the level of DMO in intraocular fluids so that DMO was found in excess of plasma levels at plasma levels which normally result in a deficit of DMO in intraocular fluids. Their action seemed to be explained in part by a blocking of the secretion out of DMO at the ciliary process and perhaps an increased diffusion in the posterior segment of the eye. Probenecid may well affect the distribution of DMO in cerebrospinal fluid. It appears that the use of the partition of DMO between compartments as an indication of pH should be substantiated by another method for each set of experimental conditions.